Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor
Joint Authors
Clarkson, Paul W.
Cheng, Hongwei
Nielsen, Torsten O.
Wang, Yuzhuo
Gao, Dongxia
Pacheco, Marina
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Tenosynovial giant cell tumor is a neoplastic disease of joints that can cause severe morbidity.
Recurrences are common following local therapy, and no effective medical therapy currently exists.
Recent work has demonstrated that all cases overexpress macrophage colony-stimulating factor (CSF1), usually as a consequence of an activating gene translocation, resulting in an influx of macrophages that form the bulk of the tumor.
New anti-CSF1 drugs have been developed; however there are no preclinical models suitable for evaluation of drug benefits in this disease.
In this paper, we describe a novel renal subcapsular xenograft model of tenosynovial giant cell tumor.
Using this model, we demonstrate that an anti-CSF1 monoclonal antibody significantly inhibits host macrophage infiltration into this tumor.
The results from this model support clinical trials of equivalent humanized agents and anti-CSF1R small molecule drugs in cases of tenosynovial giant cell tumor refractory to conventional local therapy.
American Psychological Association (APA)
Cheng, Hongwei& Clarkson, Paul W.& Gao, Dongxia& Pacheco, Marina& Wang, Yuzhuo& Nielsen, Torsten O.. 2010. Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. Complexity،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989723
Modern Language Association (MLA)
Cheng, Hongwei…[et al.]. Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. Complexity No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-989723
American Medical Association (AMA)
Cheng, Hongwei& Clarkson, Paul W.& Gao, Dongxia& Pacheco, Marina& Wang, Yuzhuo& Nielsen, Torsten O.. Therapeutic Antibodies Targeting CSF1 Impede Macrophage Recruitment in a Xenograft Model of Tenosynovial Giant Cell Tumor. Complexity. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989723