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Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature
Joint Authors
Weirich, Gregor
Bielack, Stefan S.
Behrends, Uta
Gradinger, Reiner
Wawer, Angela
von Luettichau, Irene
Jundt, Gernot
Burdach, Stefan
Prodinger, Peter M.
Grunewald, Thomas G. P.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue sarcoma mostly occurring in extraosseous sites.
SEF represents a clinically challenging entity especially because no standardized treatment regimens are available.
Intraosseous localization is an additional challenge with respect to the therapeutical approach.
We report on a 16-year-old patient with SEF of the right proximal tibia.
The patient underwent standardized neoadjuvant chemotherapy analogous to the EURAMOS-1 protocol for the treatment of osteosarcoma followed by tumor resection and endoprosthetic reconstruction.
Histopathological analysis of the resected tumor showed >90% vital tumor cells suggesting no response to chemotherapy.
Therefore, therapy was reassigned to the CWS 2002 High-Risk protocol for the treatment of soft tissue sarcoma.
To date (22 months after diagnosis), there is no evidence of relapse or metastasis.
Our data suggest that SEF may be resistant to a chemotherapy regimen containing Cisplatin, Doxorubicin, and Methotrexate, which should be considered in planning treatment for patients with SEF.
American Psychological Association (APA)
Grunewald, Thomas G. P.& von Luettichau, Irene& Weirich, Gregor& Wawer, Angela& Behrends, Uta& Prodinger, Peter M.…[et al.]. 2010. Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature. Complexity،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-989730
Modern Language Association (MLA)
Grunewald, Thomas G. P.…[et al.]. Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature. Complexity No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-989730
American Medical Association (AMA)
Grunewald, Thomas G. P.& von Luettichau, Irene& Weirich, Gregor& Wawer, Angela& Behrends, Uta& Prodinger, Peter M.…[et al.]. Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature. Complexity. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-989730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989730