Pharmacokinetics of p-Aminohippuric Acid and Inulinin Rabbits with Aristolochic Acid Nephropathy
Joint Authors
Tseng, Chiao-Shih
Chen, Shih-Ming
Hsu, Kuang-Yang
Chien, Shu-Chen
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli.
To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, New Zealand white rabbits were used in this study.
The plasma concentrations of PAH and inulin were determined by validated HPLC methods.
After a single intravenous administration of 0.5 mg/kg aristolochic acid sodium (AANa), rabbits exhibited mild to moderate nephrotoxicity on the 7th day.
Significant tubulointerstitial damage to kidney specimens was found, but there were no remarkable glomerular changes.
Clearance rates of PAH and inulin both significantly decreased in AANa-treated rabbits.
In addition, there was a significant correlation among the degree of tubulointerstitial changes and PK parameters of PAH after AANa administration, but no correlation was noted with the PKs of inulin.
With mild to moderate AAN in rabbits, the renal plasma flow significantly decreased by 55%, and the glomerular filtration rate also significantly decreased by 85%.
In conclusion, major renal lesions were found on proximal tubules after AANa administration.
The PKs of PAH and inulin significantly changed, and kidney functions, including the RPF and GFR, were reduced.
American Psychological Association (APA)
Tseng, Chiao-Shih& Chen, Shih-Ming& Chien, Shu-Chen& Hsu, Kuang-Yang. 2011. Pharmacokinetics of p-Aminohippuric Acid and Inulinin Rabbits with Aristolochic Acid Nephropathy. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-989843
Modern Language Association (MLA)
Tseng, Chiao-Shih…[et al.]. Pharmacokinetics of p-Aminohippuric Acid and Inulinin Rabbits with Aristolochic Acid Nephropathy. Advances in Pharmacological and Pharmaceutical Sciences No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-989843
American Medical Association (AMA)
Tseng, Chiao-Shih& Chen, Shih-Ming& Chien, Shu-Chen& Hsu, Kuang-Yang. Pharmacokinetics of p-Aminohippuric Acid and Inulinin Rabbits with Aristolochic Acid Nephropathy. Advances in Pharmacological and Pharmaceutical Sciences. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-989843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989843