Differential Neuroprotection of Selective Estrogen Receptor Agonists against Autonomic Dysfunction and Ischemic Cell Death inPermanent versus Reperfusion Injury
Joint Authors
Connell, Barry J.
Saleh, Tarek M.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the present study, we tested the hypothesis that selective activation of estrogen receptor subtypes (ERα and ERβ) would be neuroprotective following ischemia and/or ischemia-reperfusion, as well as prevent the associated autonomic dysfunction.
The selective ERα agonist, PPT, when administered 30 min prior to occlusion of the middle cerebral artery (pMCAO), resulted in a dose-dependent neuroprotection as measured 6 hours postpermanent MCAO, but not following 30 mins of MCAO followed by 5.5 hrs of reperfusion (I/R).
In contrast, 30 min pretreatment with the selective ERβ agonist, DPN, resulted in a dose-dependent neuroprotection following I/R, but was not protective following pMCAO.
Both drugs prevented the ischemia-induced autonomic dysfunction as measured by a decrease in the baroreceptor reflex sensitivity (BRS).
The data presented here suggest a differential role of each ER subtype in targeting the mechanisms of cell death that occur in ischemia versus reperfusion injury.
American Psychological Association (APA)
Connell, Barry J.& Saleh, Tarek M.. 2011. Differential Neuroprotection of Selective Estrogen Receptor Agonists against Autonomic Dysfunction and Ischemic Cell Death inPermanent versus Reperfusion Injury. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-989858
Modern Language Association (MLA)
Connell, Barry J.& Saleh, Tarek M.. Differential Neuroprotection of Selective Estrogen Receptor Agonists against Autonomic Dysfunction and Ischemic Cell Death inPermanent versus Reperfusion Injury. Advances in Pharmacological and Pharmaceutical Sciences No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-989858
American Medical Association (AMA)
Connell, Barry J.& Saleh, Tarek M.. Differential Neuroprotection of Selective Estrogen Receptor Agonists against Autonomic Dysfunction and Ischemic Cell Death inPermanent versus Reperfusion Injury. Advances in Pharmacological and Pharmaceutical Sciences. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-989858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989858