Molecular Imaging, Pharmacokinetics, and Dosimetry of 111In-AMBA in Human Prostate Tumor-Bearing Mice
Joint Authors
Chen, Liang-Cheng
Chen, Chun-Lin
Chuang, Cheng-Hui
Ho, Chung-Li
Lin, Wuu-Jyh
Lee, Wan-Chi
Liu, I-Hsiang
Chang, Chih-Hsien
Shen, Lie-Hang
Lee, Te-Wei
Wu, Yu-Hsien
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Molecular imaging with promise of personalized medicine can provide patient-specific information noninvasively, thus enabling treatment to be tailored to the specific biological attributes of both the disease and the patient.
This study was to investigate the characterization of DO3A-CH2CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH2 (AMBA) in vitro, MicroSPECT/CT imaging, and biological activities of 111In-AMBA in PC-3 prostate tumor-bearing SCID mice.
The uptake of 111In-AMBA reached highest with 3.87±0.65% ID/g at 8 h.
MicroSPECT/CT imaging studies suggested that the uptake of 111In-AMBA was clearly visualized between 8 and 48 h postinjection.
The distribution half-life (t1/2α) and the elimination half-life (t1/2β) of 111In-AMBA in mice were 1.53 h and 30.7 h, respectively.
The Cmax and AUC of 111In-AMBA were 7.57% ID/g and 66.39 h∗% ID/g, respectively.
The effective dose appeared to be 0.11 mSv/MBq-1.
We demonstrated a good uptake of 111In-AMBA in the GRPR-overexpressed PC-3 tumor-bearing SCID mice.
111In-AMBA is a safe, potential molecular image-guided diagnostic agent for human GRPR-positive tumors, ranging from simple and straightforward biodistribution studies to improve the efficacy of combined modality anticancer therapy.
American Psychological Association (APA)
Ho, Chung-Li& Liu, I-Hsiang& Wu, Yu-Hsien& Chen, Liang-Cheng& Chen, Chun-Lin& Lee, Wan-Chi…[et al.]. 2011. Molecular Imaging, Pharmacokinetics, and Dosimetry of 111In-AMBA in Human Prostate Tumor-Bearing Mice. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989859
Modern Language Association (MLA)
Ho, Chung-Li…[et al.]. Molecular Imaging, Pharmacokinetics, and Dosimetry of 111In-AMBA in Human Prostate Tumor-Bearing Mice. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-989859
American Medical Association (AMA)
Ho, Chung-Li& Liu, I-Hsiang& Wu, Yu-Hsien& Chen, Liang-Cheng& Chen, Chun-Lin& Lee, Wan-Chi…[et al.]. Molecular Imaging, Pharmacokinetics, and Dosimetry of 111In-AMBA in Human Prostate Tumor-Bearing Mice. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989859