Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology
Joint Authors
Gokhin, David S.
Fowler, Velia M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-17
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Efficient striated muscle contraction requires precise assembly and regulation of diverse actin filament systems, most notably the sarcomeric thin filaments of the contractile apparatus.
By capping the pointed ends of actin filaments, tropomodulins (Tmods) regulate actin filament assembly, lengths, and stability.
Here, we explore the current understanding of the expression patterns, localizations, and functions of Tmods in both cardiac and skeletal muscle.
We first describe the mechanisms by which Tmods regulate myofibril assembly and thin filament lengths, as well as the roles of closely related Tmod family variants, the leiomodins (Lmods), in these processes.
We also discuss emerging functions for Tmods in the sarcoplasmic reticulum.
This paper provides abundant evidence that Tmods are key structural regulators of striated muscle cytoarchitecture and physiology.
American Psychological Association (APA)
Gokhin, David S.& Fowler, Velia M.. 2011. Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology. BioMed Research International،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-989860
Modern Language Association (MLA)
Gokhin, David S.& Fowler, Velia M.. Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology. BioMed Research International No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-989860
American Medical Association (AMA)
Gokhin, David S.& Fowler, Velia M.. Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-989860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989860