Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications
Joint Authors
Hovland, Randi
Reikvam, Håkon
Hatfield, Kimberley Joanne
Kittang, Astrid Olsnes
Bruserud, Øystein
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-03
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients.
The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene.
This protein has multiple effects on the regulation of the proliferation, the differentiation, and the viability of leukemic cells.
The translocation can be detected as the only genetic abnormality or as part of more complex abnormalities.
If t(8;21) is detected in a patient with bone marrow pathology, the diagnosis AML can be made based on this abnormality alone.
t(8;21) is usually associated with a good prognosis.
Whether the detection of the fusion gene can be used for evaluation of minimal residual disease and risk of leukemia relapse remains to be clarified.
To conclude, detection of t(8;21) is essential for optimal handling of these patients as it has both diagnostic, prognostic, and therapeutic implications.
American Psychological Association (APA)
Reikvam, Håkon& Hatfield, Kimberley Joanne& Kittang, Astrid Olsnes& Hovland, Randi& Bruserud, Øystein. 2011. Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications. BioMed Research International،Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-989862
Modern Language Association (MLA)
Reikvam, Håkon…[et al.]. Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications. BioMed Research International No. 2011 (2011), pp.1-23.
https://search.emarefa.net/detail/BIM-989862
American Medical Association (AMA)
Reikvam, Håkon& Hatfield, Kimberley Joanne& Kittang, Astrid Olsnes& Hovland, Randi& Bruserud, Øystein. Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-989862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989862