![](/images/graphics-bg.png)
ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice
Joint Authors
Ittner, Lars M.
Liu, Xin
Götz, Jürgen
Whittle, Belinda
Dobbie, Michael
Zhang, Yafei
Tunningley, Rob
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Modifier screening is a powerful genetic tool.
While not widely used in the vertebrate system, we applied these tools to transgenic mouse strains that recapitulate key aspects of Alzheimer’s disease (AD), such as tau-expressing mice.
These are characterized by a robust pathology including both motor and memory impairment.
The phenotype can be modulated by ENU mutagenesis, which results in novel mutant mouse strains and allows identifying the underlying gene/mutation.
Here we discuss this strategy in detail.
We firstly obtained pedigrees that modify the tau-related motor phenotype, with mapping ongoing.
We further obtained transgene-independent motor pedigrees: (i) hyperactive, circling ENU 37 mice with a causal mutation in the Tbx1 gene—the complete knock-out of Tbx1 models DiGeorge Syndrome; (ii) ENU12/301 mice that show sudden jerky movements and tremor constantly; they have a causal mutation in the Kcnq1 gene, modelling aspects of the Romano-Ward and Jervell and Lange-Nielsen syndromes; and (iii) ENU16/069 mice with tremor and hypermetric gait that have a causal mutation in the Mpz (Myelin Protein Zero) gene, modelling Charcot-Marie-Tooth disease type 1 (CMT1B).
Together, we provide evidence for a real potential of an ENU mutagenesis to dissect motor functions in wild-type and tau mutant mice.
American Psychological Association (APA)
Liu, Xin& Dobbie, Michael& Tunningley, Rob& Whittle, Belinda& Zhang, Yafei& Ittner, Lars M.…[et al.]. 2011. ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice. BioMed Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-989867
Modern Language Association (MLA)
Liu, Xin…[et al.]. ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice. BioMed Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-989867
American Medical Association (AMA)
Liu, Xin& Dobbie, Michael& Tunningley, Rob& Whittle, Belinda& Zhang, Yafei& Ittner, Lars M.…[et al.]. ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-989867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989867