Attenuation of Brain Nitrostative and Oxidative Damage by Brain Cooling during Experimental Traumatic Brain Injury
Joint Authors
Lo, Chong-Jeh
Chio, Chung-Ching
Lin, Mao- Tsun
Chang, Ching-Ping
Kuo, Jinn-Rung
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the present study was to ascertain whether brain cooling causes attenuation of traumatic brain injury by reducing brain nitrostative and oxidative damage.
Brain cooling was accomplished by infusion of 5 mL of 4°C saline over 5 minutes via the external jugular vein.
Immediately after the onset of traumatic brain injury, rats were randomized into two groups and given 37°C or 4°C normal saline.
Another group of rats were used as sham operated controls.
Behavioral and biochemical assessments were conducted on 72 hours after brain injury or sham operation.
As compared to those of the sham-operated controls, the 37°C saline-treated brain injured animals displayed motor deficits, higher cerebral contusion volume and incidence, higher oxidative damage (e.g., lower values of cerebral superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, but higher values of cerebral malondialdehyde), and higher nitrostative damage (e.g., higher values of neuronal nitric oxide synthase and 3-nitrotyrosine).
All the motor deficits and brain nitrostative and oxidative damage were significantly reduced by retrograde perfusion of 4°C saline via the jugular vein.
Our data suggest that brain cooling may improve the outcomes of traumatic brain injury in rats by reducing brain nitrostative and oxidative damage.
American Psychological Association (APA)
Kuo, Jinn-Rung& Lo, Chong-Jeh& Chang, Ching-Ping& Lin, Mao- Tsun& Chio, Chung-Ching. 2011. Attenuation of Brain Nitrostative and Oxidative Damage by Brain Cooling during Experimental Traumatic Brain Injury. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989874
Modern Language Association (MLA)
Kuo, Jinn-Rung…[et al.]. Attenuation of Brain Nitrostative and Oxidative Damage by Brain Cooling during Experimental Traumatic Brain Injury. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-989874
American Medical Association (AMA)
Kuo, Jinn-Rung& Lo, Chong-Jeh& Chang, Ching-Ping& Lin, Mao- Tsun& Chio, Chung-Ching. Attenuation of Brain Nitrostative and Oxidative Damage by Brain Cooling during Experimental Traumatic Brain Injury. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989874