Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer
Joint Authors
Kuwano, Hiroyuki
Kosaka, Takayuki
Yamaki, Ei
Mogi, Akira
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Gefitinib and erlotinib, which are epidermal growth factor receptor- (EGFR-) specific tyrosine kinase inhibitors (TKIs), are widely used as molecularly targeted drugs for non-small-cell lung cancer (NSCLC).
Currently, the search for EGFR gene mutations is becoming essential for the treatment of NSCLC since these have been identified as predictive factors for drug sensitivity.
On the other hand, in almost all patients responsive to EGFR-TKIs, acquired resistance is a major clinical problem.
Mechanisms of acquired resistance reported in the past few years include secondary mutation of the EGFR gene, amplification of the MET gene, and overexpression of HGF; novel pharmaceutical agents are currently being developed to overcome resistance.
This review focuses on these mechanisms of acquired resistance to EGFR-TKIs and discusses how they can be overcome.
American Psychological Association (APA)
Kosaka, Takayuki& Yamaki, Ei& Mogi, Akira& Kuwano, Hiroyuki. 2011. Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer. BioMed Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-989883
Modern Language Association (MLA)
Kosaka, Takayuki…[et al.]. Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer. BioMed Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-989883
American Medical Association (AMA)
Kosaka, Takayuki& Yamaki, Ei& Mogi, Akira& Kuwano, Hiroyuki. Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-989883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989883