Pathophysiology of the Peritoneal Membrane during Peritoneal Dialysis: The Role of Hyaluronan
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
During peritoneal dialysis (PD), constant exposure of mesothelial cells to bioincompatible PD solutions results in the denudation of the mesothelial monolayer and impairment of mesothelial cell function.
Hyaluronan, a major component of extracellular matrices, is synthesized by mesothelial cells and contributes to remesothelialization, maintenance of cell phenotype, and tissue remodeling and provides structural support to the peritoneal membrane.
Chronic peritoneal inflammation is observed in long-term PD patients and is associated with increased hyaluronan synthesis.
During inflammation, depolymerization of hyaluronan may occur with the generation of hyaluronan fragments.
In contrast to native hyaluronan which offers a protective role to the peritoneum, hyaluronan fragments exacerbate inflammatory and fibrotic processes and therefore assist in the destruction of the tissue.
This paper will discuss the contribution of mesothelial cells to peritoneal membrane alterations that are induced by PD and the putative role of hyaluronan in these processes.
American Psychological Association (APA)
Yung, Susan& Chan, Tak Mao. 2011. Pathophysiology of the Peritoneal Membrane during Peritoneal Dialysis: The Role of Hyaluronan. BioMed Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-989891
Modern Language Association (MLA)
Yung, Susan& Chan, Tak Mao. Pathophysiology of the Peritoneal Membrane during Peritoneal Dialysis: The Role of Hyaluronan. BioMed Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-989891
American Medical Association (AMA)
Yung, Susan& Chan, Tak Mao. Pathophysiology of the Peritoneal Membrane during Peritoneal Dialysis: The Role of Hyaluronan. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-989891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989891