![](/images/graphics-bg.png)
Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications
Joint Authors
Nakamura, Akinori
Takeda, Shin'ichi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Duchenne muscular dystrophy (DMD) is a devastating X-linked muscle disorder characterized by muscle wasting which is caused by mutations in the DMD gene.
The DMD gene encodes the sarcolemmal protein dystrophin, and loss of dystrophin causes muscle degeneration and necrosis.
Thus far, therapies for this disorder are unavailable.
However, various therapeutic trials based on gene therapy, exon skipping, cell therapy, read through therapy, or pharmaceutical agents have been conducted extensively.
In the development of therapy as well as elucidation of pathogenesis in DMD, appropriate animal models are needed.
Various animal models of DMD have been identified, and mammalian (murine, canine, and feline) models are indispensable for the examination of the mechanisms of pathogenesis and the development of therapies.
Here, we review the pathological features of DMD and therapeutic applications, especially of exon skipping using antisense oligonucleotides and gene therapies using viral vectors in murine and canine models of DMD.
American Psychological Association (APA)
Nakamura, Akinori& Takeda, Shin'ichi. 2010. Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989893
Modern Language Association (MLA)
Nakamura, Akinori& Takeda, Shin'ichi. Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-989893
American Medical Association (AMA)
Nakamura, Akinori& Takeda, Shin'ichi. Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989893