Cardiac Imaging Using Clinical 1.5 T MRI Scanners in a Murine IschemiaReperfusion Model
Joint Authors
Mayr, Agnes
Haubner, Bernhard J.
Müller, Silvana
Kremser, Christian
Klug, Gert
Pachinger, Otmar
Metzler, Bernhard
Schocke, Michael
Voelkl, Jakob G. J.
Loizides, Alexander
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To perform cardiac imaging in mice without having to invest in expensive dedicated equipment, we adapted a clinical 1.5 Tesla (T) magnetic resonance imaging (MRI) scanner for use in a murine ischemia/reperfusion model.
Phase-sensitive inversion recovery (PSIR) sequence facilitated the determination of infarct sizes in vivo by late gadolinium enhancement.
Results were compared to histological infarct areas in mice after ischemia/reperfusion procedure with a good correlation (r=0.807, P<.001).
In addition, fractional area change (FAC) was assessed with single slice cine MRI and was matched to infarct size (r=−0.837) and fractional shortening (FS) measured with echocardiography (r=0.860); both P<.001.
Here, we demonstrate the use of clinical 1.5 MRI scanners as a feasible method for basic phenotyping in mice.
These widely available scanners are capable of investigating in vivo infarct dimensions as well as assessment of cardiac functional parameters in mice with reasonable throughput.
American Psychological Association (APA)
Voelkl, Jakob G. J.& Haubner, Bernhard J.& Kremser, Christian& Mayr, Agnes& Klug, Gert& Loizides, Alexander…[et al.]. 2010. Cardiac Imaging Using Clinical 1.5 T MRI Scanners in a Murine IschemiaReperfusion Model. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989895
Modern Language Association (MLA)
Voelkl, Jakob G. J.…[et al.]. Cardiac Imaging Using Clinical 1.5 T MRI Scanners in a Murine IschemiaReperfusion Model. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-989895
American Medical Association (AMA)
Voelkl, Jakob G. J.& Haubner, Bernhard J.& Kremser, Christian& Mayr, Agnes& Klug, Gert& Loizides, Alexander…[et al.]. Cardiac Imaging Using Clinical 1.5 T MRI Scanners in a Murine IschemiaReperfusion Model. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989895