The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation

Joint Authors

Yamaguchi, Akihiko
Sakuma, Kunihiro

Source

BioMed Research International

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-09-25

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

This paper summarizes the various effects of neurotrophins in skeletal muscle and how these proteins act as potential regulators of the maintenance, function, and regeneration of skeletal muscle fibers.

Increasing evidence suggests that this family of neurotrophic factors influence not only the survival and function of innervating motoneurons but also the development and differentiation of myoblasts and muscle fibers.

Muscle contractions (e.g., exercise) produce BDNF mRNA and protein in skeletal muscle, and the BDNF seems to play a role in enhancing glucose metabolism and may act for myokine to improve various brain disorders (e.g., Alzheimer's disease and major depression).

In adults with neuromuscular disorders, variations in neurotrophin expression are found, and the role of neurotrophins under such conditions is beginning to be elucidated.

This paper provides a basis for a better understanding of the role of these factors under such pathological conditions and for treatment of human neuromuscular disease.

American Psychological Association (APA)

Sakuma, Kunihiro& Yamaguchi, Akihiko. 2011. The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation. BioMed Research International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-989918

Modern Language Association (MLA)

Sakuma, Kunihiro& Yamaguchi, Akihiko. The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation. BioMed Research International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-989918

American Medical Association (AMA)

Sakuma, Kunihiro& Yamaguchi, Akihiko. The Recent Understanding of the Neurotrophin's Role in Skeletal Muscle Adaptation. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-989918

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-989918