Effects of Fruit and Vegetable Low Molecular Mass Fractions on Gene Expression in Gingival Cells Challenged with Prevotella intermedia and Actinomyces naeslundii
Joint Authors
Canesi, Laura
Wilson, Michael
Stauder, Monica
Signoretto, Caterina
Pratten, Jonathan
Papetti, Adele
Lingström, Peter
Zaura, Egija
Borghi, Cristina
Spratt, David A.
Pruzzo, Carla
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Low molecular mass (LMM) fractions obtained from extracts of raspberry, red chicory, and Shiitake mushrooms have been shown to be an useful source of specific antibacterial, antiadhesion/coaggregation, and antibiofilm agent(s) that might be used for protection towards caries and gingivitis.
In this paper, the effects of such LMM fractions on human gingival KB cells exposed to the periodontal pathogens Prevotella intermedia and Actinomyces naeslundii were evaluated.
Expression of cytokeratin 18 (CK18) and β4 integrin (β4INT) genes, that are involved in cell proliferation/differentiation and adhesion, and of the antimicrobial peptide β2 defensin (HβD2) in KB cells was increased upon exposure to either live or heat-killed bacteria.
All LMM fractions tested prevented or reduced the induction of gene expression by P.
intermedia and A.
naeslundii depending on the experimental conditions.
Overall, the results suggested that LMM fractions could modulate the effects of bacteria associated with periodontal disease in gingival cells.
American Psychological Association (APA)
Canesi, Laura& Borghi, Cristina& Stauder, Monica& Lingström, Peter& Papetti, Adele& Pratten, Jonathan…[et al.]. 2011. Effects of Fruit and Vegetable Low Molecular Mass Fractions on Gene Expression in Gingival Cells Challenged with Prevotella intermedia and Actinomyces naeslundii. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989940
Modern Language Association (MLA)
Canesi, Laura…[et al.]. Effects of Fruit and Vegetable Low Molecular Mass Fractions on Gene Expression in Gingival Cells Challenged with Prevotella intermedia and Actinomyces naeslundii. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-989940
American Medical Association (AMA)
Canesi, Laura& Borghi, Cristina& Stauder, Monica& Lingström, Peter& Papetti, Adele& Pratten, Jonathan…[et al.]. Effects of Fruit and Vegetable Low Molecular Mass Fractions on Gene Expression in Gingival Cells Challenged with Prevotella intermedia and Actinomyces naeslundii. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989940
