Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection
Joint Authors
O'Brien, Alison D.
Mohawk, Krystle L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-10
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Escherichia coli O157:H7 has been responsible for multiple food- and waterborne outbreaks of diarrhea and/or hemorrhagic colitis (HC) worldwide.
More importantly, a portion of E.
coli O157:H7-infected individuals, particularly young children, develop a life-threatening sequela of infection called hemolytic uremic syndrome (HUS).
Shiga toxin (Stx), a potent cytotoxin, is the major virulence factor linked to the presentation of both HC and HUS.
Currently, treatment of E.
coli O157:H7 and other Stx-producing E.
coli (STEC) infections is limited to supportive care.
To facilitate development of therapeutic strategies and vaccines for humans against these agents, animal models that mimic one or more aspect of STEC infection and disease are needed.
In this paper, we focus on the characteristics of various mouse models that have been developed and that can be used to monitor STEC colonization, disease, pathology, or combinations of these features as well as the impact of Stx alone.
American Psychological Association (APA)
Mohawk, Krystle L.& O'Brien, Alison D.. 2010. Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection. BioMed Research International،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-989957
Modern Language Association (MLA)
Mohawk, Krystle L.& O'Brien, Alison D.. Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection. BioMed Research International No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-989957
American Medical Association (AMA)
Mohawk, Krystle L.& O'Brien, Alison D.. Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-989957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989957