Synthesis and Evaluation of Amino Acid-Based Radiotracer 99mTc-N4-AMT for Breast Cancer Imaging
Joint Authors
Yu, Dong-Fang
Chanda, Mithu
Yang, David J.
Zhang, Yin-Han
Ali, Mohammad S.
Kong, Fan-Lin
Oh, Chang-Sok
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
This study was to develop an efficient synthesis of 99mTc-O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine (99mTc-N4-AMT) and evaluate its potential in cancer imaging.
Methods.
N4-AMT was synthesized by reacting N4-oxalate and 3-bromopropyl AMT (N-BOC, ethyl ester).
In vitro cellular uptake kinetics of 99mTc-N4-AMT was assessed in rat mammary tumor cells.
Tissue distribution of the radiotracer was determined in normal rats at 0.5–4 h, while planar imaging was performed in mammary tumor-bearing rats at 30–120 min.
Results.
The total synthesis yield of N4-AMT was 14%.
Cellular uptake of 99mTc-N4-AMT was significantly higher than that of 99mTc-N4.
Planar imaging revealed that 99mTc-N4-AMT rendered greater tumor/muscle ratios than 99mTc-N4.
Conclusions.
N4-AMT could be synthesized with a considerably high yield.
Our in vitro and in vivo data suggest that 99mTc-N4-AMT, a novel amino acid-based radiotracer, efficiently enters breast cancer cells, effectively distinguishes mammary tumors from normal tissues, and thus holds the promise for breast cancer imaging.
American Psychological Association (APA)
Kong, Fan-Lin& Ali, Mohammad S.& Zhang, Yin-Han& Oh, Chang-Sok& Yu, Dong-Fang& Chanda, Mithu…[et al.]. 2011. Synthesis and Evaluation of Amino Acid-Based Radiotracer 99mTc-N4-AMT for Breast Cancer Imaging. BioMed Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-989966
Modern Language Association (MLA)
Kong, Fan-Lin…[et al.]. Synthesis and Evaluation of Amino Acid-Based Radiotracer 99mTc-N4-AMT for Breast Cancer Imaging. BioMed Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-989966
American Medical Association (AMA)
Kong, Fan-Lin& Ali, Mohammad S.& Zhang, Yin-Han& Oh, Chang-Sok& Yu, Dong-Fang& Chanda, Mithu…[et al.]. Synthesis and Evaluation of Amino Acid-Based Radiotracer 99mTc-N4-AMT for Breast Cancer Imaging. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-989966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989966