BACs as Tools for the Study of Genomic Imprinting
Joint Authors
Tunster, S. J.
Van De Pette, M.
John, R. M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Genomic imprinting in mammals results in the expression of genes from only one parental allele.
Imprinting occurs as a consequence of epigenetic marks set down either in the father's or the mother's germ line and affects a very specific category of mammalian gene.
A greater understanding of this distinctive phenomenon can be gained from studies using large genomic clones, called bacterial artificial chromosomes (BACs).
Here, we review the important applications of BACs to imprinting research, covering physical mapping studies and the use of BACs as transgenes in mice to study gene expression patterns, to identify imprinting centres, and to isolate the consequences of altered gene dosage.
We also highlight the significant and unique advantages that rapid BAC engineering brings to genomic imprinting research.
American Psychological Association (APA)
Tunster, S. J.& Van De Pette, M.& John, R. M.. 2010. BACs as Tools for the Study of Genomic Imprinting. BioMed Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-989975
Modern Language Association (MLA)
Tunster, S. J.…[et al.]. BACs as Tools for the Study of Genomic Imprinting. BioMed Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-989975
American Medical Association (AMA)
Tunster, S. J.& Van De Pette, M.& John, R. M.. BACs as Tools for the Study of Genomic Imprinting. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-989975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989975