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Microarray Analysis for a Comprehensive Immunological-Status Evaluation during Cancer Vaccine Immune Monitoring
Joint Authors
Marincola, Francesco M.
Monsurrò, Vladia
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Anticancer immune responses can be enhanced by immune intervention that promotes complex biological mechanisms involving several cellular populations.
The classical immune monitoring for biological-based cancer clinical trials is often based on single-cell analysis.
However, the overall effect could be lost by such a reductionist approach explaining the lack of correlation among clinical and immunological endpoints often reported.
Microarray technology could give the possibility of studying in a multiparametric setting the immune therapy effects.
The application of microarray is leading to an improved understanding of the immune responses to tumor immunotherapy.
In fact, analysis of cancer vaccine-induced host responses using microarrays is proposed as valuable alternative to the standard cell-based methods.
This paper shows successful examples of how high-throughput gene expression profiling contributed to the understanding of anticancer immune responses during biological therapy, introducing as well the integrative platforms that allow the network analysis in molecular biology studies.
American Psychological Association (APA)
Monsurrò, Vladia& Marincola, Francesco M.. 2011. Microarray Analysis for a Comprehensive Immunological-Status Evaluation during Cancer Vaccine Immune Monitoring. BioMed Research International،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-990000
Modern Language Association (MLA)
Monsurrò, Vladia& Marincola, Francesco M.. Microarray Analysis for a Comprehensive Immunological-Status Evaluation during Cancer Vaccine Immune Monitoring. BioMed Research International No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-990000
American Medical Association (AMA)
Monsurrò, Vladia& Marincola, Francesco M.. Microarray Analysis for a Comprehensive Immunological-Status Evaluation during Cancer Vaccine Immune Monitoring. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-990000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990000