The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases
Joint Authors
Álvarez, Enrique
Castelló, Alfredo
Carrasco, Luis
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-27
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
After entry into animal cells, most viruses hijack essential components involved in gene expression.
This is the case of poliovirus, which abrogates cellular translation soon after virus internalization.
Abrogation is achieved by cleavage of both eIF4GI and eIF4GII by the viral protease 2A.
Apart from the interference of poliovirus with cellular protein synthesis, other gene expression steps such as RNA and protein trafficking between nucleus and cytoplasm are also altered.
Poliovirus 2Apro is capable of hydrolyzing components of the nuclear pore, thus preventing an efficient antiviral response by the host cell.
Here, we compare in detail poliovirus 2Apro with other viral proteins (from picornaviruses and unrelated families) as regard to their activity on key host factors that control gene expression.
It is possible that future analyses to determine the cellular proteins targeted by 2Apro will uncover other cellular functions ablated by poliovirus infection.
Further understanding of the cellular proteins hydrolyzed by 2Apro will add further insight into the molecular mechanism by which poliovirus and other viruses interact with the host cell.
American Psychological Association (APA)
Castelló, Alfredo& Álvarez, Enrique& Carrasco, Luis. 2011. The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases. BioMed Research International،Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-990041
Modern Language Association (MLA)
Castelló, Alfredo…[et al.]. The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases. BioMed Research International No. 2011 (2011), pp.1-23.
https://search.emarefa.net/detail/BIM-990041
American Medical Association (AMA)
Castelló, Alfredo& Álvarez, Enrique& Carrasco, Luis. The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-990041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990041