Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women
Joint Authors
Conconi, Donatella
Lissoni, Sara
Bentivegna, Angela
Martinoli, Emanuela
Marozzi, Anna
Panzeri, Elena
Crosti, Francesca
Volontè, Marinella
Redaelli, Serena
Sala, Elena
Dalprà, Leda
Saccheri, Fabiana
Baronchelli, Simona
Villa, Nicoletta
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The importance of X chromosome in the aetiology of premature ovarian failure (POF) is well-known but in many cases POF still remains idiopathic.
Chromosome aneuploidy increase is a physiological phenomenon related to aging, but the role of low-level sex chromosome mosaicism in ovarian function is still undiscovered.
Standard cytogenetic analysis was carried out in a total of 269 patients affected by POF: 27 chromosomal abnormalities were identified, including X chromosome and autosomal structural and numerical abnormalities.
In 47 patients with 46,XX karyotype we performed interphase FISH using X alpha-satellite probe in order to identify X chromosome mosaicism rate.
Aneuploidy rate in the patient group was significantly higher than the general population group.
These findings underline the importance of X chromosome in the aetiology of POF and highlight the potential role of low-level sex chromosome mosaicism in ovarian aging that may lead to a premature onset of menopause.
American Psychological Association (APA)
Baronchelli, Simona& Conconi, Donatella& Panzeri, Elena& Bentivegna, Angela& Redaelli, Serena& Lissoni, Sara…[et al.]. 2010. Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990042
Modern Language Association (MLA)
Baronchelli, Simona…[et al.]. Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990042
American Medical Association (AMA)
Baronchelli, Simona& Conconi, Donatella& Panzeri, Elena& Bentivegna, Angela& Redaelli, Serena& Lissoni, Sara…[et al.]. Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990042