Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites
Joint Authors
Niikura, Mamoru
Inoue, Shin-Ichi
Kobayashi, Fumie
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Interleukin- (IL-) 10, anti-inflammatory cytokine, is known to inhibit the protective immune responses against malaria parasites and to be involved in exacerbating parasitemia during Plasmodium infection.
In contrast, IL-10 is regarded as necessary for suppressing severe pathology during Plasmodium infection.
Here, we summarize the role of IL-10 during murine malaria infection, focusing especially on coinfection with lethal and nonlethal strains of malaria parasites.
Recent studies have demonstrated that the major sources of IL-10 are subpopulations of CD4+ T cells in humans and mice infected with Plasmodium.
We also discuss the influence of innate immunity on the induction of CD4+ T cells during murine malaria coinfection.
American Psychological Association (APA)
Niikura, Mamoru& Inoue, Shin-Ichi& Kobayashi, Fumie. 2011. Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990051
Modern Language Association (MLA)
Niikura, Mamoru…[et al.]. Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990051
American Medical Association (AMA)
Niikura, Mamoru& Inoue, Shin-Ichi& Kobayashi, Fumie. Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990051