Shen-Fu Injection Preconditioning Inhibits Myocardial Ischemia-Reperfusion Injury in Diabetic Rats: Activation of eNOS via the PI3KAkt Pathway
Joint Authors
Xu, Jinjin
Lei, Shaoqing
Dou, Juan
Wu, Yang
Xia, Zhong-yuan
Meng, Qing-tao
Zhu, Jie
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this paper is to investigate whether Shen-fu injection (SFI), a traditional Chinese medicine, could attenuate myocardial ischemia-reperfusion (MI/R) injury in diabetes.
Streptozotocin-induced diabetic rats were randomly assigned to the Sham, I/R, SFI preconditioning, and SFI plus wortmannin (a phosphatidylinositol 3-kinase inhibitor) groups.
After the treatment, hearts were subjected to 30 min of coronary artery occlusion and 2 h reperfusion except the Sham group.
Myocardial infarct size and cardiomyocytes apoptosis were increased significantly in MI/R group as compared with the Sham group.
SFI preconditioning significantly decreased infarct size, apoptosis, caspase-3 protein expression, MDA level in myocardial tissues, and plasma level of CK and LDH but increased p-Akt, p-eNOS, bcl-2 protein expression, and SOD activity compared to I/R group.
Moreover, SFI-induced cardioprotection was abolished by wortmannin.
We conclude that SFI preconditioning protects diabetic hearts from I/R injury via PI3K/Akt-dependent pathway.
American Psychological Association (APA)
Wu, Yang& Xia, Zhong-yuan& Meng, Qing-tao& Zhu, Jie& Lei, Shaoqing& Xu, Jinjin…[et al.]. 2010. Shen-Fu Injection Preconditioning Inhibits Myocardial Ischemia-Reperfusion Injury in Diabetic Rats: Activation of eNOS via the PI3KAkt Pathway. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990053
Modern Language Association (MLA)
Wu, Yang…[et al.]. Shen-Fu Injection Preconditioning Inhibits Myocardial Ischemia-Reperfusion Injury in Diabetic Rats: Activation of eNOS via the PI3KAkt Pathway. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990053
American Medical Association (AMA)
Wu, Yang& Xia, Zhong-yuan& Meng, Qing-tao& Zhu, Jie& Lei, Shaoqing& Xu, Jinjin…[et al.]. Shen-Fu Injection Preconditioning Inhibits Myocardial Ischemia-Reperfusion Injury in Diabetic Rats: Activation of eNOS via the PI3KAkt Pathway. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990053