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HDAC Activity Is Required for Efficient Core Promoter Function at the Mouse Mammary Tumor Virus Promoter
Joint Authors
Smith, Catharine L.
Magklara, Angeliki
Lee, Sang C.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Histone deacetylases (HDACs) have been shown to be required for basal or inducible transcription at a variety of genes by poorly understood mechanisms.
We demonstrated previously that HDAC inhibition rapidly repressed transcription from the mouse mammary tumor virus (MMTV) promoter by a mechanism that does not require the binding of upstream transcription factors.
In the current study, we find that HDACs work through the core promoter sequences of MMTV as well as those of several cellular genes to facilitate transcriptional initiation through deacetylation of nonhistone proteins.
American Psychological Association (APA)
Lee, Sang C.& Magklara, Angeliki& Smith, Catharine L.. 2010. HDAC Activity Is Required for Efficient Core Promoter Function at the Mouse Mammary Tumor Virus Promoter. BioMed Research International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990084
Modern Language Association (MLA)
Lee, Sang C.…[et al.]. HDAC Activity Is Required for Efficient Core Promoter Function at the Mouse Mammary Tumor Virus Promoter. BioMed Research International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-990084
American Medical Association (AMA)
Lee, Sang C.& Magklara, Angeliki& Smith, Catharine L.. HDAC Activity Is Required for Efficient Core Promoter Function at the Mouse Mammary Tumor Virus Promoter. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990084