A Rabbit Model of Thrombosis on Atherosclerotic Lesions
Joint Authors
Yamashita, Atsushi
Asada, Yujiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Thrombus formation on a disrupted atherosclerotic plaque is a key event that leads to atherothrombosis.
Because thrombus is induced by chemical or physical injury of normal arteries in most animal models of thrombosis, the mechanisms of thrombogenesis and thrombus growth in atherosclerotic vessels should be investigated in diseased arteries of appropriate models.
Pathological findings of human atherothrombosis suggest that tissue factor, an initiator of the coagulation cascade, significantly affects enhanced platelet aggregation and fibrin formation after plaque disruption.
We established a rabbit model of atherothrombosis based on human pathology in which differences in thrombus formation between normal and atherosclerotic arteries, factors contributing to thrombus growth, and mechanisms of plaque erosion can be investigated.
Emerging transgenic and stem cell technologies should also provide an invaluable rabbit experimental model in the near future.
American Psychological Association (APA)
Yamashita, Atsushi& Asada, Yujiro. 2010. A Rabbit Model of Thrombosis on Atherosclerotic Lesions. BioMed Research International،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-990090
Modern Language Association (MLA)
Yamashita, Atsushi& Asada, Yujiro. A Rabbit Model of Thrombosis on Atherosclerotic Lesions. BioMed Research International No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-990090
American Medical Association (AMA)
Yamashita, Atsushi& Asada, Yujiro. A Rabbit Model of Thrombosis on Atherosclerotic Lesions. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-990090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990090