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Profile of a Serial Killer: Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination
Joint Authors
Speiser, Daniel E.
Rufer, Nathalie
Wieckowski, Sébastien
Baumgaertner, Petra
Iancu, Emanuela M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-05
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
T-cell vaccination may prevent or treat cancer and infectious diseases, but further progress is required to increase clinical efficacy.
Step-by-step improvements of T-cell vaccination in phase I/II clinical studies combined with very detailed analysis of T-cell responses at the single cell level are the strategy of choice for the identification of the most promising vaccine candidates for testing in subsequent large-scale phase III clinical trials.
Major aims are to fully identify the most efficient T-cells in anticancer therapy, to characterize their TCRs, and to pinpoint the mechanisms of T-cell recruitment and function in well-defined clinical situations.
Here we discuss novel strategies for the assessment of human T-cell responses, revealing in part unprecedented insight into T-cell biology and novel structural principles that govern TCR-pMHC recognition.
Together, the described approaches advance our knowledge of T-cell mediated-protection from human diseases.
American Psychological Association (APA)
Iancu, Emanuela M.& Baumgaertner, Petra& Wieckowski, Sébastien& Speiser, Daniel E.& Rufer, Nathalie. 2010. Profile of a Serial Killer: Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination. BioMed Research International،Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-990099
Modern Language Association (MLA)
Iancu, Emanuela M.…[et al.]. Profile of a Serial Killer: Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination. BioMed Research International No. 2011 (2011), pp.1-21.
https://search.emarefa.net/detail/BIM-990099
American Medical Association (AMA)
Iancu, Emanuela M.& Baumgaertner, Petra& Wieckowski, Sébastien& Speiser, Daniel E.& Rufer, Nathalie. Profile of a Serial Killer: Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-990099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990099