Mesenchymal Stem Cells: Angels or Demons?
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mesenchymal stem cells (MSCs) have been used in cell-based therapy in various disease conditions such as graft-versus-host and heart diseases, osteogenesis imperfecta, and spinal cord injuries, and the results have been encouraging.
However, as MSC therapy gains popularity among practitioners and researchers, there have been reports on the adverse effects of MSCs especially in the context of tumour modulation and malignant transformation.
These cells have been found to enhance tumour growth and metastasis in some studies and have been related to anticancer-drug resistance in other instances.
In addition, various studies have also reported spontaneous malignant transformation of MSCs.
The mechanism of the modulatory behaviour and the tumorigenic potential of MSCs, warrant urgent exploration, and the use of MSCs in patients with cancer awaits further evaluation.
However, if MSCs truly play a role in tumour modulation, they can also be potential targets of cancer treatment.
American Psychological Association (APA)
Wong, Rebecca S. Y.. 2011. Mesenchymal Stem Cells: Angels or Demons?. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990106
Modern Language Association (MLA)
Wong, Rebecca S. Y.. Mesenchymal Stem Cells: Angels or Demons?. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990106
American Medical Association (AMA)
Wong, Rebecca S. Y.. Mesenchymal Stem Cells: Angels or Demons?. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990106