Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus
Joint Authors
Fujio, Keishi
Okamoto, Akiko
Yamamoto, Kazuhiko
Okamura, Tomohisa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition, resulting in tissue and organ damage.
An understanding of the mechanisms responsible for homeostatic control of inflammation, which involve both innate and adoptive immune responses, will enable the development of novel therapies for SLE.
Regulatory T cells (Treg) play critical roles in the induction of peripheral tolerance to self- and foreign antigens.
Naturally occurring CD4+CD25+ Treg, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been intensively studied because their deficiency abrogates self-tolerance and causes autoimmune disease.
Moreover, regulatory cytokines such as interleukin-10 (IL-10) also play a central role in controlling inflammatory processes.
This paper focuses on Tregs and Treg-associated cytokines which might regulate the pathogenesis of SLE and, hence, have clinical applications.
American Psychological Association (APA)
Okamoto, Akiko& Fujio, Keishi& Okamura, Tomohisa& Yamamoto, Kazuhiko. 2011. Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990114
Modern Language Association (MLA)
Okamoto, Akiko…[et al.]. Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990114
American Medical Association (AMA)
Okamoto, Akiko& Fujio, Keishi& Okamura, Tomohisa& Yamamoto, Kazuhiko. Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990114