Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The human genome is epigenetically organized through a series of modifications to the histone proteins that interact with the DNA.
In cancer, many of the proteins that regulate these modifications can be altered in both function and expression.
One example of this is the family of histone deacetylases (HDACs), which as their name implies remove acetyl groups from the histone proteins, allowing for more condensed nucleosomal structure.
HDACs have increased expression in cancer and are also believed to promote carcinogenesis through the acetylation and interaction with key transcriptional regulators.
Given this, small molecule histone deacetylases inhibitors have been identified and developed, which not only inhibit HDACs, but can also lead to growth arrest, differentiation, and/or apoptosis in tumors both in vitro and in vivo.
Here, we will discuss some of the recent developments in clinical trials utilizing HDACs inhibitors for the treatment of both hematological malignancies as well as solid tumors.
American Psychological Association (APA)
Federico, Mario& Bagella, Luigi. 2010. Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors. BioMed Research International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990131
Modern Language Association (MLA)
Federico, Mario& Bagella, Luigi. Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors. BioMed Research International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-990131
American Medical Association (AMA)
Federico, Mario& Bagella, Luigi. Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990131