Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver
Joint Authors
Kobayashi, Shinichi
Harimoto, Yoshie
Takenoshita-Nakaya, Sachiko
Kinoshita, Yuichi
Tanaka, Masami
Takeba, Yuko
Tatsunami, Shinobu
Kumai, Toshio
Matsumoto, Naoki
Watanabe, Minoru
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated the effects of orange juice (OJ) or hesperidin, a component of OJ, on the pharmacokinetics of pravastatin (PRV) and the expression of both protein and mRNA of multidrug resistance-associated protein 2 (Mrp2) in the rat small intestine and liver.
Eight-week-old male Sprague-Dawley rats were used in this study.
OJ or a 0.079% hesperidin suspension was administered orally for 2 days.
Tap water was given as a control.
A single dose of PRV at 100 mg/kg p.o.
was administered after 2 days of OJ, hesperidin, or tap water ingestion.
The AUC, Cmax, and t1/2 values of PRV were significantly increased in OJ group.
Mrp2 protein and mRNA levels in the small intestine and liver, respectively, were significantly decreased after the ingestion of OJ.
The same results were obtained with hesperidin.
These results suggest that the changes in PRV pharmacokinetic parameters and the decrease in Mrp2 expression caused by OJ are due to hesperidin in the juice.
American Psychological Association (APA)
Watanabe, Minoru& Matsumoto, Naoki& Takeba, Yuko& Kumai, Toshio& Tanaka, Masami& Tatsunami, Shinobu…[et al.]. 2011. Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990157
Modern Language Association (MLA)
Watanabe, Minoru…[et al.]. Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990157
American Medical Association (AMA)
Watanabe, Minoru& Matsumoto, Naoki& Takeba, Yuko& Kumai, Toshio& Tanaka, Masami& Tatsunami, Shinobu…[et al.]. Orange Juice and Its Component, Hesperidin, Decrease the Expression of Multidrug Resistance-Associated Protein 2 in Rat Small Intestine and Liver. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990157
