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A Metabonomic Approach to Analyze the Dexamethasone-Induced Cleft Palate in Mice
Joint Authors
Lu, Shengjun
He, Wei
Xiao, Liying
Shi, Bing
Li, Wei
Lu, Junjun
Xu, Bin
Huang, Jing
Zhou, Jinglin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mice models are an important way to understand the relation between the fetus with cleft palate and changes of maternal biofluid.
This paper aims to develop a metabonomics approach to analyze dexamethasone-induced cleft palate in pregnant C57BL/6J mice and to study the relationship between the change of endogenous small molecular metabolites in maternal plasma and the incidence of cleft palate.
To do so, pregnant mice were randomly divided into two groups.
The one group was injected with dexamethasone.
On E17.5th day, the incident rates of cleft palate from embryos in two groups were calculated.
The H1-NMR spectra from the metabolites in plasma in two groups was collected at same time.
Then the data were analyzed using metabonomics methods (PCA and SIMCA).
The results showed that the data from the two groups displayed distinctive characters, and the incidence of cleft palate were significantly different (P<.005).
To conclude, this study demonstrates that the metabonomics approach is a powerful and effective method in detecting the abnormal metabolites from mother in the earlier period of embryos, and supports the idea that a change from dexamethasone induced in maternal metabolites plays an important role in the incidence of cleft palate.
American Psychological Association (APA)
Zhou, Jinglin& Xu, Bin& Shi, Bing& Huang, Jing& He, Wei& Lu, Shengjun…[et al.]. 2010. A Metabonomic Approach to Analyze the Dexamethasone-Induced Cleft Palate in Mice. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990165
Modern Language Association (MLA)
Zhou, Jinglin…[et al.]. A Metabonomic Approach to Analyze the Dexamethasone-Induced Cleft Palate in Mice. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990165
American Medical Association (AMA)
Zhou, Jinglin& Xu, Bin& Shi, Bing& Huang, Jing& He, Wei& Lu, Shengjun…[et al.]. A Metabonomic Approach to Analyze the Dexamethasone-Induced Cleft Palate in Mice. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990165