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Loss of the NHE2 Na+H+ Exchanger in Mice Results in Dilation of Folliculo-Stellate Cell Canaliculi
Joint Authors
Shull, Gary E.
Schultheis, Patrick J.
Andringa, Anastasia
Miller, Marian L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Genetic ablation of the NHE2 Na+/H+ exchanger causes gastric achlorhydria, absorptive defects in kidney and colon, and low fertility.
Here we show that NHE2 is expressed in the pituitary, with the highest mRNA expression in pars distalis and lower expression in pars intermedia.
In pars distalis of NHE2-null mice, prominent cyst-like dilatations of folliculo-stellate (FS) cell canaliculi developed with age, and there were increased FS cell area, accumulation of lipid in FS cell cytoplasm, redundancies in FS cell basement membrane, and other changes.
The expansion of the canaliculi indicates that NHE2 is a major absorptive Na+/H+ exchanger in the luminal membranes lining the extensive network of channels formed by FS cells, which may provide a means of intrapituitary communication.
The results suggest that NHE2 contributes to homeostatic regulation of the volume and composition of the canalicular fluid and may counter the secretory activity of the CFTR Cl− channel, which is known to be expressed in pituitary.
American Psychological Association (APA)
Miller, Marian L.& Andringa, Anastasia& Schultheis, Patrick J.& Shull, Gary E.. 2010. Loss of the NHE2 Na+H+ Exchanger in Mice Results in Dilation of Folliculo-Stellate Cell Canaliculi. BioMed Research International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990166
Modern Language Association (MLA)
Miller, Marian L.…[et al.]. Loss of the NHE2 Na+H+ Exchanger in Mice Results in Dilation of Folliculo-Stellate Cell Canaliculi. BioMed Research International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-990166
American Medical Association (AMA)
Miller, Marian L.& Andringa, Anastasia& Schultheis, Patrick J.& Shull, Gary E.. Loss of the NHE2 Na+H+ Exchanger in Mice Results in Dilation of Folliculo-Stellate Cell Canaliculi. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990166