Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors
Joint Authors
Chandra, Joya
Manton, Christa A.
Rivera-Del Valle, Nilsa
Miller, Claudia P.
Singh, Melissa M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Histone acetylation is a posttranslational modification that plays a role in regulating gene expression.
More recently, other nonhistone proteins have been identified to be acetylated which can regulate their function, stability, localization, or interaction with other molecules.
Modulating acetylation with histone deacetylase inhibitors (HDACi) has been validated to have anticancer effects in preclinical and clinical cancer models.
This has led to development and approval of the first HDACi, vorinostat, for the treatment of cutaneous T cell lymphoma.
However, to date, targeting acetylation with HDACi as a monotherapy has shown modest activity against other cancers.
To improve their efficacy, HDACi have been paired with other antitumor agents.
Here, we discuss several combination therapies, highlighting various epigenetic drugs, ROS-generating agents, proteasome inhibitors, and DNA-damaging compounds that together may provide a therapeutic advantage over single-agent strategies.
American Psychological Association (APA)
Miller, Claudia P.& Singh, Melissa M.& Rivera-Del Valle, Nilsa& Manton, Christa A.& Chandra, Joya. 2011. Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors. BioMed Research International،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-990167
Modern Language Association (MLA)
Miller, Claudia P.…[et al.]. Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors. BioMed Research International No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-990167
American Medical Association (AMA)
Miller, Claudia P.& Singh, Melissa M.& Rivera-Del Valle, Nilsa& Manton, Christa A.& Chandra, Joya. Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-990167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990167