DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities
Joint Authors
Suhartono, Maggy T.
Trisina, Jessica
Tjandrawinata, Raymond R.
Sunardi, Febrina
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The medicinal value of earthworm has been widely known since the history of Asian ancient medicine.
This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033.
The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity.
Fibrin plate and clot lysis assay were also done to examine thrombolytic properties.
DLBS1033 was found to possess fibrinogenolytic activity on α-, β-, and γ-chain of fibrinogen.
It also induced antiplatelet aggregation and prolonged blood clotting time, which further confirmed its antithrombotic properties.
In addition, thrombolytic properties of DLBS1033 were shown with its fast and long-acting fibrinolytic activity, as well as its effective blood clot lysis activities.
In conclusion, DLBS1033 conferred antithrombotic and thrombolytic action which could be used as a safe and promising oral thrombolytic drug.
American Psychological Association (APA)
Trisina, Jessica& Sunardi, Febrina& Suhartono, Maggy T.& Tjandrawinata, Raymond R.. 2011. DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities. BioMed Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990170
Modern Language Association (MLA)
Trisina, Jessica…[et al.]. DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities. BioMed Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-990170
American Medical Association (AMA)
Trisina, Jessica& Sunardi, Febrina& Suhartono, Maggy T.& Tjandrawinata, Raymond R.. DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-990170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990170