A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration
Joint Authors
Lehmann, Hugo
Spanswick, Simon C.
Sutherland, Robert J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats.
This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deficits revealed in a number of tasks that depend on intact hippocampal function.
The gradual nature of ADX-induced cell death and the ensuing deficits in cognition resemble in some important respects a variety of pathological conditions in humans.
Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model.
We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind.
American Psychological Association (APA)
Spanswick, Simon C.& Lehmann, Hugo& Sutherland, Robert J.. 2011. A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration. BioMed Research International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990180
Modern Language Association (MLA)
Spanswick, Simon C.…[et al.]. A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration. BioMed Research International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-990180
American Medical Association (AMA)
Spanswick, Simon C.& Lehmann, Hugo& Sutherland, Robert J.. A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990180