Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice
Joint Authors
Okada, Seiji
Suzu, Shinya
Kariya, Ryusho
Harada, Hideki
Ono, Ayumi
Taura, Manabu
Iwanaga, Sumako
Hattori, Shinichiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Immunodeficient mice are becoming invaluable tools in human stem cell and tumor research.
In this study, we generated Rag-2/Jak3 double-deficient (Rag-2−/−Jak3−/−) mice with a C57/BL6 and Balb/c genetic background and compared the human lymphohematopoietic cell engraftment rate.
Human cord blood-derived CD34+ hematopoietic stem cells were successfully engrafted into Balb/c Rag-2−/−Jak3−/− mice; however, the engraftment rate was far lower in C57/BL6 Rag-2−/−Jak3−/− mice.
Transplantation of human peripheral blood mononuclear cells resulted in the same tendency.
Thus, a Balb/c background offers superior engraftment capacity than a C57/BL6 background and provides an attractive model for human hematopoietic cell engraftment.
American Psychological Association (APA)
Ono, Ayumi& Hattori, Shinichiro& Kariya, Ryusho& Iwanaga, Sumako& Taura, Manabu& Harada, Hideki…[et al.]. 2011. Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice. BioMed Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990188
Modern Language Association (MLA)
Ono, Ayumi…[et al.]. Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice. BioMed Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-990188
American Medical Association (AMA)
Ono, Ayumi& Hattori, Shinichiro& Kariya, Ryusho& Iwanaga, Sumako& Taura, Manabu& Harada, Hideki…[et al.]. Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990188