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Current Concepts: Mouse Models of Sjögren's Syndrome
Joint Authors
Lee, Byung Ha
Nguyen, Cuong Q.
Lavoie, Tegan N.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Sjögren's syndrome (SjS) is a complex chronic autoimmune disease of unknown etiology which primarily targets the exocrine glands, resulting in eventual loss of secretory function.
The disease can present as either primary SjS or secondary SjS, the latter of which occurs concomitantly with another autoimmune disease such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma, or primary biliary cirrhosis.
Current advancements in therapeutic prevention and treatment for SjS are impeded by lack of understanding in the pathophysiological and clinical progression of the disease.
Development of appropriate mouse models for both primary and secondary SjS is needed in order to advance knowledge of this disease.
This paper details important features, advantages, and pitfalls of current animal models of SjS, including spontaneous, transgenic, knockout, immunization, and transplantation chimera mouse models, and emphasizes the need for a better model in representing the human SjS phenotype.
American Psychological Association (APA)
Lavoie, Tegan N.& Lee, Byung Ha& Nguyen, Cuong Q.. 2010. Current Concepts: Mouse Models of Sjögren's Syndrome. BioMed Research International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990191
Modern Language Association (MLA)
Lavoie, Tegan N.…[et al.]. Current Concepts: Mouse Models of Sjögren's Syndrome. BioMed Research International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-990191
American Medical Association (AMA)
Lavoie, Tegan N.& Lee, Byung Ha& Nguyen, Cuong Q.. Current Concepts: Mouse Models of Sjögren's Syndrome. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-990191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990191