Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification
Joint Authors
Ku, Chia-Chen
Tsai, Eing-Mei
Yokoyama, Kazunari K.
Huang, Yu-Chang
Hasegawa, Hitomi
Wang, Shin-Wei
Saito, Shigeo
Hou, Ming-Feng
Chiou, Shyh-Shin
Lin, Ying-Chu
Yamaguchi, Naoto
Wu, Deng-Chyang
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Transcription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences.
JDP2 plays a key role as a repressor of adipocyte differentiation by regulation of the expression of the gene C/EBPδ via inhibition of histone acetylation.
Moreover, JDP2-deficient mouse embryonic fibroblasts (JDP2−/− MEFs) are resistant to replicative senescence.
JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16Ink4a, resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27).
Therefore, it seems that chromatin-remodeling factors, including the PRC complex controlled by JDP2, may be important players in the senescence program.
The novel mechanisms that underline the action of JDP2 in inducing cellular senescence and suppressing adipocyte differentiation are reviewed.
American Psychological Association (APA)
Huang, Yu-Chang& Hasegawa, Hitomi& Wang, Shin-Wei& Ku, Chia-Chen& Lin, Ying-Chu& Chiou, Shyh-Shin…[et al.]. 2010. Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification. BioMed Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990197
Modern Language Association (MLA)
Huang, Yu-Chang…[et al.]. Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification. BioMed Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-990197
American Medical Association (AMA)
Huang, Yu-Chang& Hasegawa, Hitomi& Wang, Shin-Wei& Ku, Chia-Chen& Lin, Ying-Chu& Chiou, Shyh-Shin…[et al.]. Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990197