TP53 Mutations in Nonsmall Cell Lung Cancer
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The tumor suppressor gene TP53 is frequently mutated in human cancers.
Abnormality of the TP53 gene is one of the most significant events in lung cancers and plays an important role in the tumorigenesis of lung epithelial cells.
Human lung cancers are classified into two major types, small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC).
The latter accounts for approximately 80% of all primary lung cancers, and the incidence of NSCLC is increasing yearly.
Most clinical studies suggest that NSCLC with TP53 alterations carries a worse prognosis and may be relatively more resistant to chemotherapy and radiation.
A deep understanding of the role of TP53 in lung carcinogenesis may lead to a more reasonably targeted clinical approach, which should be exploited to enhance the survival rates of patients with lung cancer.
This paper will focus on the role of TP53 in the molecular pathogenesis, epidemiology, and therapeutic strategies of TP53 mutation in NSCLC.
American Psychological Association (APA)
Mogi, Akira& Kuwano, Hiroyuki. 2010. TP53 Mutations in Nonsmall Cell Lung Cancer. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990206
Modern Language Association (MLA)
Mogi, Akira& Kuwano, Hiroyuki. TP53 Mutations in Nonsmall Cell Lung Cancer. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990206
American Medical Association (AMA)
Mogi, Akira& Kuwano, Hiroyuki. TP53 Mutations in Nonsmall Cell Lung Cancer. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990206