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p53: The Attractive Tumor Suppressor in the Cancer Research Field
Joint Authors
Ozaki, Toshinori
Nakagawara, Akira
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
p53 is one of the most studied tumor suppressors in the cancer research field.
Of note, over 50% of human tumors carry loss of function mutations, and thus p53 has been considered to be a classical Knudson-type tumor suppressor.
From the functional point of view, p53 is a nuclear transcription factor to transactivate a variety of its target genes implicated in the induction of cell cycle arrest, DNA repair, and apoptotic cell death.
In response to cellular stresses such as DNA damage, p53 is activated and promotes cell cycle arrest followed by the replacement of DNA lesions and/or apoptotic cell death.
Therefore, p53 is able to maintain the genomic integrity to prevent the accumulation of genetic alterations, and thus stands at a crossroad between cell survival and cell death.
In this paper, we describe a variety of molecular mechanisms behind the regulation of p53.
American Psychological Association (APA)
Ozaki, Toshinori& Nakagawara, Akira. 2010. p53: The Attractive Tumor Suppressor in the Cancer Research Field. BioMed Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990215
Modern Language Association (MLA)
Ozaki, Toshinori& Nakagawara, Akira. p53: The Attractive Tumor Suppressor in the Cancer Research Field. BioMed Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-990215
American Medical Association (AMA)
Ozaki, Toshinori& Nakagawara, Akira. p53: The Attractive Tumor Suppressor in the Cancer Research Field. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990215