Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease
Joint Authors
Shimizu, Takahiko
Ito, Genzo
Noda, Yoshihiro
Toda, Toshihiko
Maeda, Masahiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice.
Here, we demonstrate that the PS2 mutation induced the early deposition of amyloid β-protein (Aβ) at 2-3 months of age and progressive accumulation at 4-5 months of age in the brains of the mutant mice.
The PS2 mutation also accelerated learning and memory impairment associated with Aβ accumulation at 4-5 months of age in Tg2576 mice.
These results suggest that the PS2 mutation causes early cerebral amyloid accumulation and memory dysfunction.
PS2Tg2576 mice are a suitable mouse model for studying amyloid-lowering therapies.
American Psychological Association (APA)
Toda, Toshihiko& Noda, Yoshihiro& Ito, Genzo& Maeda, Masahiro& Shimizu, Takahiko. 2010. Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease. BioMed Research International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990219
Modern Language Association (MLA)
Toda, Toshihiko…[et al.]. Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease. BioMed Research International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-990219
American Medical Association (AMA)
Toda, Toshihiko& Noda, Yoshihiro& Ito, Genzo& Maeda, Masahiro& Shimizu, Takahiko. Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990219