Autologous Peripheral Blood Mononuclear Cell Recognition of Autologous Proliferating Tumor Cells in the Context of a Patient-Specific Vaccine Trial
Joint Authors
Lee, G.
Cornforth, A. N.
Dillman, R. O.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Metastatic melanoma patients who were treated with patient-specific vaccines consisting of dendritic cells loaded with autologous tumor cells had a 5-year survival of over 50%.
Enzyme-linked immunospot (ELISPOT) has been used to detect antigen reactive T cells as a means of determining immune response.
We wished to determine whether IFN-gamma secretion in an ELISPOT assay was prognostic or predictive for survival following treatment.
Peripheral blood mononuclear cells (PBMCs) collected at weeks 0 and 4 were evaluated by ELISPOT assay for response to autologous tumor cells.
Overall, there was slight increase in the number of tumor reactive lymphocytes from week 0 to week 4.
Using >5 spots/100 K PBMC as the cutoff, a log-rank analysis revealed only a slight statistical significance in overall survival for patients who lacked tumor reactive PBMCs at week 4.
The sensitivity of ELISPOT in the context of patient-specific cellular vaccines is unclear.
American Psychological Association (APA)
Cornforth, A. N.& Lee, G.& Dillman, R. O.. 2011. Autologous Peripheral Blood Mononuclear Cell Recognition of Autologous Proliferating Tumor Cells in the Context of a Patient-Specific Vaccine Trial. BioMed Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990227
Modern Language Association (MLA)
Cornforth, A. N.…[et al.]. Autologous Peripheral Blood Mononuclear Cell Recognition of Autologous Proliferating Tumor Cells in the Context of a Patient-Specific Vaccine Trial. BioMed Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-990227
American Medical Association (AMA)
Cornforth, A. N.& Lee, G.& Dillman, R. O.. Autologous Peripheral Blood Mononuclear Cell Recognition of Autologous Proliferating Tumor Cells in the Context of a Patient-Specific Vaccine Trial. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990227