Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications
Joint Authors
Roberti, María Paula
Levy, Estrella Mariel
Mordoh, José
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Natural killer (NK) cells are central components of the innate immunity.
In murine models, it has been shown that NK cells can control both local tumor growth and metastasis due to their ability to exert direct cellular cytotoxicity without prior sensitization and to secrete immunostimulatory cytokines like IFN-γ.
The latter participates in cancer elimination by inhibiting cellular proliferation and angiogenesis, promoting apoptosis, and stimulating the adaptive immune system, and it is instrumental for enhancing Ag processing and presentation.
Nevertheless, NK cells display impaired functionality and capability to infiltrate tumors in cancer patients.
Also, NK cells are feasible targets of stimulation to participate in immunotherapeutic approaches like antibody-based strategies and adoptive cell transfer.
Thus, multiple attempts currently aim to manipulate NK for utilization in the immunotherapy of cancer.
American Psychological Association (APA)
Levy, Estrella Mariel& Roberti, María Paula& Mordoh, José. 2011. Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications. BioMed Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990239
Modern Language Association (MLA)
Levy, Estrella Mariel…[et al.]. Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications. BioMed Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990239
American Medical Association (AMA)
Levy, Estrella Mariel& Roberti, María Paula& Mordoh, José. Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990239