Chemiluminescent Nanomicelles for Imaging Hydrogen Peroxide and Self-Therapy in Photodynamic Therapy
Joint Authors
Wu, Wei
Jiang, Xiqun
Zhang, Luzhong
Chen, Rui
Gao, Jian
Hu, Yong
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hydrogen peroxide is a signal molecule of the tumor, and its overproduction makes a higher concentration in tumor tissue compared to normal tissue.
Based on the fact that peroxalates can make chemiluminescence with a high efficiency in the presence of hydrogen peroxide, we developed nanomicelles composed of peroxalate ester oligomers and fluorescent dyes, called peroxalate nanomicelles (POMs), which could image hydrogen peroxide with high sensitivity and stability.
The potential application of the POMs in photodynamic therapy (PDT) for cancer was also investigated.
It was found that the PDT-drug-loaded POMs were sensitive to hydrogen peroxide, and the PDT drug could be stimulated by the chemiluminescence from the reaction between POMs and hydrogen peroxide, which carried on a self-therapy of the tumor without the additional laser light resource.
American Psychological Association (APA)
Chen, Rui& Zhang, Luzhong& Gao, Jian& Wu, Wei& Hu, Yong& Jiang, Xiqun. 2011. Chemiluminescent Nanomicelles for Imaging Hydrogen Peroxide and Self-Therapy in Photodynamic Therapy. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990241
Modern Language Association (MLA)
Chen, Rui…[et al.]. Chemiluminescent Nanomicelles for Imaging Hydrogen Peroxide and Self-Therapy in Photodynamic Therapy. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990241
American Medical Association (AMA)
Chen, Rui& Zhang, Luzhong& Gao, Jian& Wu, Wei& Hu, Yong& Jiang, Xiqun. Chemiluminescent Nanomicelles for Imaging Hydrogen Peroxide and Self-Therapy in Photodynamic Therapy. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990241