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Synergic Effect of Genistein and Daidzein on UVB-Induced DNA Damage: An Effective Photoprotective Combination
Joint Authors
Iovine, Barbara
Monfrecola, Giuseppe
Iannella, Maria Luigia
Gasparri, Franco
Bevilacqua, Maria Assunta
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The anti-inflammatory effects and antioxidant activities of individual isoflavones are well established although little is known about the photoprotective effect of their combination.
The aim of this study was to investigate the photoprotective effects of different concentrations of genistein and daidzein individually or combined.
We measured the expression levels of the cyclo-oxygenase-2 (COX-2) and growth arrest and DNA-damage inducible (Gadd45) genes, which are involved in inflammation and DNA repair, respectively, in BJ-5ta human skin fibroblasts irradiated with 60 mJ/cm2 UVB.
We also determined the cellular response to UVB-induced DNA damage by Comet assay.
We report that genistein and daidzein when administered combined, and at a specific concentration and ratio, exerted a synergistic photoprotective effect that was greater than the effect obtained with each isoflavone alone.
The results reported herein suggest that low concentrations of genistein and daidzein combined may be good candidate ingredients for protective agents against UV-induced photodamage.
American Psychological Association (APA)
Iovine, Barbara& Iannella, Maria Luigia& Gasparri, Franco& Monfrecola, Giuseppe& Bevilacqua, Maria Assunta. 2011. Synergic Effect of Genistein and Daidzein on UVB-Induced DNA Damage: An Effective Photoprotective Combination. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990249
Modern Language Association (MLA)
Iovine, Barbara…[et al.]. Synergic Effect of Genistein and Daidzein on UVB-Induced DNA Damage: An Effective Photoprotective Combination. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990249
American Medical Association (AMA)
Iovine, Barbara& Iannella, Maria Luigia& Gasparri, Franco& Monfrecola, Giuseppe& Bevilacqua, Maria Assunta. Synergic Effect of Genistein and Daidzein on UVB-Induced DNA Damage: An Effective Photoprotective Combination. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990249