A Window into the Heterogeneity of Human Cerebrospinal Fluid Aβ Peptides
Joint Authors
Stoppani, Elena
Paterlini, Anna
Ghidoni, Roberta
Benussi, Luisa
Agnati, Luigi F.
Binetti, Giuliano
Albertini, Valentina
Fuxe, Kjell
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The initiating event in Alzheimer's disease (AD) is an imbalance in the production and clearance of amyloid beta (Aβ) peptides leading to the formation of neurotoxic brain Aβ assemblies.
Cerebrospinal Fluid (CSF), which is a continuum of the brain, is an obvious source of markers reflecting central neuropathologic features of brain diseases.
In this review, we provide an overview and update on our current understanding of the pathobiology of human CSF Aβ peptides.
Specifically, we focused our attention on the heterogeneity of the CSF Aβ world discussing (1) basic research studies and what has been translated to clinical practice, (2) monomers and other soluble circulating Aβ assemblies, and (3) communication modes for Aβ peptides and their microenvironment targets.
Finally, we suggest that Aβ peptides as well as other key signals in the central nervous system (CNS), mainly involved in learning and hence plasticity, may have a double-edged sword action on neuron survival and function.
American Psychological Association (APA)
Ghidoni, Roberta& Paterlini, Anna& Albertini, Valentina& Stoppani, Elena& Binetti, Giuliano& Fuxe, Kjell…[et al.]. 2011. A Window into the Heterogeneity of Human Cerebrospinal Fluid Aβ Peptides. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990251
Modern Language Association (MLA)
Ghidoni, Roberta…[et al.]. A Window into the Heterogeneity of Human Cerebrospinal Fluid Aβ Peptides. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990251
American Medical Association (AMA)
Ghidoni, Roberta& Paterlini, Anna& Albertini, Valentina& Stoppani, Elena& Binetti, Giuliano& Fuxe, Kjell…[et al.]. A Window into the Heterogeneity of Human Cerebrospinal Fluid Aβ Peptides. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990251