Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy
Joint Authors
Lamberti, Vincenzo
Zambrano, Nicola
Vitale, Monica
D'Orio, Concetta
Galeotafiore, Antonella
Genovese, Arturo
Spadaro, Giuseppe
Di Giovanni, Stefano
Scaloni, Andrea
Marone, Gianni
D'Ambrosio, Chiara
Capasso, Mario
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Common variable immunodeficiency is the most common form of symptomatic primary antibody failure in adults and children.
Replacement immunoglobulin is the standard treatment of these patients.
By using a differential proteomic approach based on 2D-DIGE, we examined serum samples from normal donors and from matched, naive, and immunoglobulin-treated patients.
The results highlighted regulated expression of serum proteins in naive patients.
Among the identified proteins, clusterin/ApoJ serum levels were lower in naive patients, compared to normal subjects.
This finding was validated in a wider collection of samples from newly enrolled patients.
The establishment of a cellular system, based on a human hepatocyte cell line HuH7, allowed to ascertain a potential role in the regulation of CLU gene expression by immunoglobulins.
American Psychological Association (APA)
Spadaro, Giuseppe& D'Orio, Concetta& Genovese, Arturo& Galeotafiore, Antonella& D'Ambrosio, Chiara& Di Giovanni, Stefano…[et al.]. 2011. Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy. BioMed Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990255
Modern Language Association (MLA)
Spadaro, Giuseppe…[et al.]. Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy. BioMed Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-990255
American Medical Association (AMA)
Spadaro, Giuseppe& D'Orio, Concetta& Genovese, Arturo& Galeotafiore, Antonella& D'Ambrosio, Chiara& Di Giovanni, Stefano…[et al.]. Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990255