Bioactive Food Components and Cancer-Specific Metabonomic Profiles
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cancer cells possess unique metabolic signatures compared to normal cells, including shifts in aerobic glycolysis, glutaminolysis, and de novo biosynthesis of macromolecules.
Targeting these changes with agents (drugs and dietary components) has been employed as strategies to reduce the complications associated with tumorigenesis.
This paper highlights the ability of several food components to suppress tumor-specific metabolic pathways, including increased expression of glucose transporters, oncogenic tyrosine kinase, tumor-specific M2-type pyruvate kinase, and fatty acid synthase, and the detection of such effects using various metabonomic technologies, including liquid chromatography/mass spectrometry (LC/MS) and stable isotope-labeled MS.
Stable isotope-mediated tracing technologies offer exciting opportunities for defining specific target(s) for food components.
Exposures, especially during the early transition phase from normal to cancer, are critical for the translation of knowledge about food components into effective prevention strategies.
Although appropriate dietary exposures needed to alter cellular metabolism remain inconsistent and/or ill-defined, validated metabonomic biomarkers for dietary components hold promise for establishing effective strategies for cancer prevention.
American Psychological Association (APA)
Kim, Young S.& Milner, John A.. 2010. Bioactive Food Components and Cancer-Specific Metabonomic Profiles. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990260
Modern Language Association (MLA)
Kim, Young S.& Milner, John A.. Bioactive Food Components and Cancer-Specific Metabonomic Profiles. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990260
American Medical Association (AMA)
Kim, Young S.& Milner, John A.. Bioactive Food Components and Cancer-Specific Metabonomic Profiles. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990260