How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance
Joint Authors
Wang, Rui
Hong, Manqing
Natarajan, Kannan
Margulies, David H.
Revilleza, Maria Jamela
Mans, Janet
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Natural killer (NK) cells provide an initial host immune response to infection by many viral pathogens.
Consequently, the viruses have evolved mechanisms to attenuate the host response, leading to improved viral fitness.
One mechanism employed by members of the β-herpesvirus family, which includes the cytomegaloviruses, is to modulate the expression of cell surface ligands recognized by NK cell activation molecules.
A novel set of cytomegalovirus (CMV) genes, exemplified by the mouse m145 family, encode molecules that have structural and functional features similar to those of host major histocompatibility-encoded (MHC) class I molecules, some of which are known to contribute to immune evasion.
In this review, we explore the function, structure, and evolution of MHC-I-like molecules of the CMVs and speculate on the dynamic development of novel immunoevasive functions based on the MHC-I protein fold.
American Psychological Association (APA)
Revilleza, Maria Jamela& Wang, Rui& Mans, Janet& Hong, Manqing& Natarajan, Kannan& Margulies, David H.. 2011. How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance. BioMed Research International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990262
Modern Language Association (MLA)
Revilleza, Maria Jamela…[et al.]. How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance. BioMed Research International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-990262
American Medical Association (AMA)
Revilleza, Maria Jamela& Wang, Rui& Mans, Janet& Hong, Manqing& Natarajan, Kannan& Margulies, David H.. How the Virus Outsmarts the Host: Function and Structure of Cytomegalovirus MHC-I-Like Molecules in the Evasion of Natural Killer Cell Surveillance. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-990262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990262