Muscle Plasticity and β2-Adrenergic Receptors: Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy
Joint Authors
Shirato, Ken
Tachiyashiki, Kaoru
Imaizumi, Kazuhiko
Sato, Shogo
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We discuss the functional roles of β2-adrenergic receptors in skeletal muscle hypertrophy and atrophy as well as the adaptive responses of β2-adrenergic receptor expression to anabolic and catabolic conditions.
β2-Adrenergic receptor stimulation using anabolic drugs increases muscle mass by promoting muscle protein synthesis and/or attenuating protein degradation.
These effects are prevented by the downregulation of the receptor.
Endurance training improves oxidative performance partly by increasing β2-adrenergic receptor density in exercise-recruited slow-twitch muscles.
However, excessive stimulation of β2-adrenergic receptors negates their beneficial effects.
Although the preventive effects of β2-adrenergic receptor stimulation on atrophy induced by muscle disuse and catabolic hormones or drugs are observed, these catabolic conditions decrease β2-adrenergic receptor expression in slow-twitch muscles.
These findings present evidence against the use of β2-adrenergic agonists in therapy for muscle wasting and weakness.
Thus, β2-adrenergic receptors in the skeletal muscles play an important physiological role in the regulation of protein and energy balance.
American Psychological Association (APA)
Sato, Shogo& Shirato, Ken& Tachiyashiki, Kaoru& Imaizumi, Kazuhiko. 2011. Muscle Plasticity and β2-Adrenergic Receptors: Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy. BioMed Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990266
Modern Language Association (MLA)
Sato, Shogo…[et al.]. Muscle Plasticity and β2-Adrenergic Receptors: Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy. BioMed Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-990266
American Medical Association (AMA)
Sato, Shogo& Shirato, Ken& Tachiyashiki, Kaoru& Imaizumi, Kazuhiko. Muscle Plasticity and β2-Adrenergic Receptors: Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990266